Jonathan M. Budzik

This study shows Optineurin deficiency disrupts the endolysosomal network and impairs xenophagy, leading to increased Mycobacterium tuberculosis growth and necrotic cell death.

This study shows Tax1bp1 promotes Mtb growth in alveolar macrophages and enhances inflammatory responses, while restricting Mtb in bone marrow-derived macrophages.

This study identifies a genetic switch involving IS1245 transposition and Erp/MarP that controls colony morphology, virulence, and antibiotic resistance in Mycobacterium avium.

This paper describes a method to efficiently generate genetically modified primary human myeloid cells using CRISPR-Cas9 RNP nucleofection, demonstrating its utility in studying HIV-1 infection and myeloid cell biology.

The paper uses proteomic analysis to identify TAX1BP1 as a mediator of autophagy targeting M. tuberculosis during macrophage infection.