J. Ernst

This study shows Optineurin deficiency disrupts the endolysosomal network and impairs xenophagy, leading to increased Mycobacterium tuberculosis growth and necrotic cell death.

This study shows that the local lung environment, not the peripheral environment, drives phenotypic diversity in monocyte-derived lung cells during Mtb infection.

The paper identifies impaired IFNγ responsiveness in CD11clo monocyte-derived lung cells as a mechanism allowing Mycobacterium tuberculosis persistence during chronic infection.

The paper identifies Rare Variable Mtb Antigens (RVMA) that induce Th17 responses in human TB infection, suggesting their potential as vaccine antigens to enhance Th17 immunity.

This study identifies MHC-II antigens from Mycobacterium tuberculosis using mass spectrometry and evaluates mRNA vaccine immunogens to enhance T cell recognition.

This study shows Tax1bp1 promotes Mtb growth in alveolar macrophages and enhances inflammatory responses, while restricting Mtb in bone marrow-derived macrophages.

A vaccine using rare variable antigens (RVMA) reduces lung pathology in mice without lowering bacterial loads during Mtb infection.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

Xiao et al. reveal spatial segregation of immune cells in TB-lung tissue and link the microenvironmental dynamics to disease states of tuberculosis.

This study investigates the roles of CCR2 and CX3CR1 in monocyte-derived cell trafficking during pulmonary tuberculosis, showing CCR2's role in lung and lymph node accumulation and CX3CR1's impact on positioning in lymph nodes.

The paper introduces CRESTA, a method to analyze CD4 T cell epitope specificities and phenotypes, revealing diverse responses to Mycobacterium tuberculosis.

The paper presents streamlined methods for generating circular DNA from the rv0678 gene to improve genotypic bedaquiline resistance testing in Mycobacterium tuberculosis.

The paper develops a proteomics workflow using orthogonal proteases to generate spectral libraries, enabling comprehensive plasma proteome analysis and identifying TB-related proteins.

This paper describes a method to efficiently generate genetically modified primary human myeloid cells using CRISPR-Cas9 RNP nucleofection, demonstrating its utility in studying HIV-1 infection and myeloid cell biology.