Christine S. Flaxman

Expression of non-neuronal Tau in humans and mice

The paper confirms non-neuronal Tau expression in multiple tissues of humans and mice using validated antibodies and tissue microarrays.

Morpho-functional timeline of progressive cystic fibrosis pancreatic exocrine and endocrine pathology derived from semi-quantitative scoring and AI-driven quantitativeimage analysis

This study uses histopathological scoring and AI analysis to map the progression of pancreatic changes in cystic fibrosis across age, identifying key fibrotic and fatty tissue transformations linked to exocrine and endocrine dysfunction.

Small things matter: Lack of extra-islet beta cells in Type 1 diabetes

Image analysis of 262,832 pancreatic endocrine objects across 220 donors reveals that small beta-cell-only clusters are abundant in early childhood but virtually absent in type 1 diabetes.

Developmentally dynamic changes in DNA methylation in the human pancreas

The paper quantifies DNA methylation changes in human fetal pancreas development, identifying developmental differentially methylated positions and their genomic distribution.

A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1

The paper identifies non-coding mutations in a regulatory element of HK1 that lead to inappropriate expression in pancreatic beta-cells and cause congenital hyperinsulinism.