PhysiologyProceedings of the National Academy of SciencesPeer-reviewed
Neonatal Enteric Infection Disrupts the Microbiota-Gut-Brain Axis Through Pattern Recognition Receptors and Altered Neuroimmune Signaling
Jungjae Park, Olivia Orahood, Maithili Banginwar…·Mélanie G. Gareau
This study shows that neonatal EPEC infection disrupts the microbiota-gut-brain axis via NOD1 signaling, leading to long-term neuroimmune and behavioral deficits, and identifies probiotic muropeptides as potential therapeutics.
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