Author

Prabhath Mannam

Boston Children's HospitalORCID 0009-0002-1200-3180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Daniel ZeveiD· 2 shared David T. BreaultiD· 2 shared Diana L. CarloneiD· 2 shared Amy E. O’ConnelliD· 1 shared Amy ShepherdiD· 1 shared Bianca Frintu· 1 shared Claudio Henrique T. RibeiroiD· 1 shared Elisa Saint‐Denis· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Daniel ZeveORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 5, 2026

EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA

Guilherme Piovezani Ramos, Daniel Zeve, Amy Shepherd…·David T. Breault

This study identifies EGFR inhibitors as inducers of enteroendocrine cell differentiation, linking their use to treatment-associated diarrhea through STAT1 signaling activation.

DOI 10.64898/2026.06.02.729650

humanmouse

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Developmental BiologyNature CommunicationsPeer-reviewedJan 11, 2022

Robust differentiation of human enteroendocrine cells from intestinal stem cells

Daniel Zeve, Eric Stas, Joshua de Sousa Casal…·David T. Breault

This study develops a method to differentiate human intestinal stem cells into functional enteroendocrine cells using small molecule targeting of specific signaling pathways.

69 citationstop 3%

humanbulk RNA-seq

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