Diana L. Carlone

EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA

This study identifies EGFR inhibitors as inducers of enteroendocrine cell differentiation, linking their use to treatment-associated diarrhea through STAT1 signaling activation.

Rho-ROCK signaling and α-Catenin mediate β-Catenin-driven hyperplasia in the adrenal via adherens junctions

This study shows that β-Catenin-driven hyperplasia in the adrenal cortex is mediated through Rho-ROCK signaling and Cat-dependent stabilization of adherens junctions.

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

Loss of WNT2B Increases Progression from Dysplasia to Colorectal Cancer

This study shows that loss of WNT2B promotes colorectal cancer progression in mouse models and is associated with poor patient survival in human samples.

Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production

This study identifies WNT2B as a key regulator of adrenal aldosterone production, showing its role in zG function and linking its variants to primary aldosteronism and a new form of familial hypoaldosteronism.

WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans

This study shows WNT2B deficiency in mice increases colitis susceptibility and impairs human intestinal development, with distinct effects in small intestine and colon.

Telomerase reverse transcriptase (TERT)-expressing cells mark a novel stem cell population in the adult mouse brain

This study identifies TERT-expressing cells as a novel multipotent stem cell population in the adult mouse brain, capable of differentiating into multiple cell types.

Robust differentiation of human enteroendocrine cells from intestinal stem cells

This study develops a method to differentiate human intestinal stem cells into functional enteroendocrine cells using small molecule targeting of specific signaling pathways.