Amy Shepherd

Neural Activation of Human Primary Intestinal Enteroendocrine L-cells

This study identifies cholinergic and adrenergic neural signals that activate human intestinal L-cells, triggering hormone secretion and calcium waves.

Neurokinin 1 receptor blockade is associated with increased survival of patients with C. difficile infection

This study shows that blocking the Neurokinin 1 receptor with antagonists improves survival in C. difficile infection patients and reduces vascular inflammation.

EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA

This study identifies EGFR inhibitors as inducers of enteroendocrine cell differentiation, linking their use to treatment-associated diarrhea through STAT1 signaling activation.

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

This study shows that enteric glia regulate Paneth cell secretion and microbial ecology but have minimal effects on overall intestinal epithelial transcription.

Androgen regulation of bowel function in mice and humans

This study shows androgens regulate colonic motility in mice and humans, with lower testosterone levels linked to IBS symptom severity.