Daniel Zeve

This study identifies cholinergic and adrenergic neural signals that activate human intestinal L-cells, triggering hormone secretion and calcium waves.

This study identifies EGFR inhibitors as inducers of enteroendocrine cell differentiation, linking their use to treatment-associated diarrhea through STAT1 signaling activation.

This study shows that early-life mucosal T cells promote intestinal stem cell renewal and secretory differentiation through direct interactions and signaling, with impaired function in NEC and adult T cells.

This study identifies Blautia wexlerae's role in converting dietary fats into bioactive metabolites that enhance gut hormone secretion and improve metabolic health in mice and humans.

The paper creates a cellular and spatial map of the duodenum in children, revealing environmental and developmental influences on intestinal cell states.

The paper shows that colitis leaves an epigenetic memory in colonic stem cells that promotes tumor growth by enhancing regenerative gene programs and AP-1 activity.

This study develops a method to differentiate human intestinal stem cells into functional enteroendocrine cells using small molecule targeting of specific signaling pathways.