BiochemistryScience AdvancesPeer-reviewed
Ubiquitin Receptor-Induced Proximity is Sufficient for Ubiquitin-Independent Targeted Protein Degradation via the 26S Proteasome
Seh Hoon Park, Yejin Jang, Soo-Yeon Lee…·Min Jae Lee
This paper introduces Protea-Tac, a Ub-independent protein degrader that targets proteins to the proteasome, demonstrating in vivo tumor suppression.