Insuk Byun

This paper introduces Protea-Tac, a Ub-independent protein degrader that targets proteins to the proteasome, demonstrating in vivo tumor suppression.

The paper identifies USP15 as a fourth proteasome-associated DUB, showing it binds transiently to proteasomes and selectively disassembles short polyubiquitin chains.

This study shows that reducing RAD23A in TDP-43 mice improves survival, behavior, and reduces TDP-43 pathology and transcriptomic alterations.