Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor
Zhaotong Cong, Li-Nan Chen, Honglei Ma, Qingtong Zhou, Xinyu Zou, Chenyu Ye, Antao Dai, Qing Liu, Wei Huang, Xianqiang Sun, Xi Wang, Peiyu Xu, Lihua Zhao, Tian Xia, Wenge Zhong, , Ming‐Wei Wang
The paper reports cryo-EM structures of GLP-1R with ago-allosteric modulators, revealing their mechanism of action and providing insights for therapeutic design.
Nature Communications · Jun 18, 2021Peer-reviewedMolecular Biology