Author

Zhengxin Dong

Ministry of Education of the People's Republic of ChinaORCID 0009-0002-1921-3340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1

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Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

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Hao WangiD· 1 shared Jingyi ShiiD· 1 shared Lei CheniD· 1 shared Tao SuniD· 1 shared Weiwen ZhangiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperSynthetic Biology

Hao WangORCID

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1 paper

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Synthetic BiologyACS Synthetic BiologyPeer-reviewedJan 9, 2025

Genome-wide A to G and C to T Mutations Induced by Functional TadA Variants in Escherichia coli

Hao Wang, Zhengxin Dong, Jingyi Shi…·Weiwen Zhang

This paper develops a system for inducing A[->]G and C[->]T mutations in E. coli using fusion proteins of DnaG with TadA variants, significantly increasing mutation rates and enabling rapid adaptive evolution.

4 citations

E. coliwhole-genome sequencing

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