Author

Alice M. Youle

National Institutes of HealthORCID 0009-0002-2766-5785Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Acadia L. GrimmeiD· 1 shared Ben T. Pockrass· 1 shared J. Robert HoggiD· 1 shared Joseph H. ChapmaniD· 1 shared Keir Cajal NeumaniD· 1 shared Rachel O. NiedereriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperMolecular Biology

Acadia L. GrimmeORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 19, 2026

Systematic Interrogation Uncovers Targetable Translational Control Elements within the CFTR 5' UTR

Ben T. Pockrass, Alice M. Youle, Rachel O. Niederer

The paper identifies translational regulatory elements in the CFTR 5' UTR using DART, discovering stimulatory and repressive features with potential therapeutic applications.

DOI 10.64898/2026.10.16.759746

humanexperimental assay

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Molecular BiologyNucleic Acids ResearchPeer-reviewedFeb 13, 2024

UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency

Joseph H. Chapman, Alice M. Youle, Acadia L. Grimme…·J. Robert Hogg

This study investigates how UPF1's ATPase autoinhibition and activation affect RNA binding kinetics and NMD efficiency, revealing that UPF1-RNA interaction kinetics are critical for NMD.

15 citations

statistical model

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