Author

Joseph H. Chapman

National Institutes of HealthORCID 0000-0003-1542-4749Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Robert HoggiD· 2 shared Keir Cajal NeumaniD· 2 shared Acadia L. GrimmeiD· 1 shared Alice M. YouleiD· 1 shared Clara D. WangiD· 1 shared Jens H. GundlachiD· 1 shared Jonathan M. CraigiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

J. Robert HoggORCID

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2 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedFeb 13, 2024

UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency

Joseph H. Chapman, Alice M. Youle, Acadia L. Grimme…·J. Robert Hogg

This study investigates how UPF1's ATPase autoinhibition and activation affect RNA binding kinetics and NMD efficiency, revealing that UPF1-RNA interaction kinetics are critical for NMD.

15 citations

statistical model

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Molecular BiologyNucleic Acids ResearchPeer-reviewedOct 29, 2022

UPF1 mutants with intact ATPase but deficient helicase activities promote efficient nonsense-mediated mRNA decay

Joseph H. Chapman, Jonathan M. Craig, Clara D. Wang…·J. Robert Hogg

The paper identifies UPF1 mutants with impaired helicase activity but intact ATPase activity that still support efficient nonsense-mediated mRNA decay in human cells.

26 citations

humanexperimental assay

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