Acadia L. Grimme

CLASHub integrates CLASH datasets with expression data to study miRNA-target interactions and identifies a novel TDMD trigger for miR-335-3p degradation.

The paper identifies tts-2 as a TDMD trigger that drives decay of the mir-35-42 miRNA family in C. elegans embryos through base pairing with their seed sequence.

This study shows that miRNA Argonaute slicing has a minor role in star strand destabilization in C. elegans, with limited developmental impact and context-dependent effects.

This study shows that NHL-2's RNA-binding activity is essential for miRNA-mediated gene regulation in C. elegans, linking it to translational repression and miRISC complex function.

This study investigates how UPF1's ATPase autoinhibition and activation affect RNA binding kinetics and NMD efficiency, revealing that UPF1-RNA interaction kinetics are critical for NMD.

The paper shows that the decay of the mir-35 miRNA family in C. elegans is seed sequence-dependent and selectively regulates all members of the family during development.