Author

Rachel O. Niederer

Yale UniversityORCID 0000-0002-4574-0518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:differential expression· 2 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:Ribo-seq· 1

Frequent Co-Authors

Wendy V. GilbertiD· 3 shared Alice M. YouleiD· 1 shared Andrei Stanciu· 1 shared Ben T. Pockrass· 1 shared Boris ZinshteyniD· 1 shared Brett D. LindenbachiD· 1 shared Cole J.T. LewisiD· 1 shared Colin Echeverría AitkeniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Wendy V. GilbertORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Systematic Interrogation Uncovers Targetable Translational Control Elements within the CFTR 5' UTR

Ben T. Pockrass, Alice M. Youle, Rachel O. Niederer

The paper identifies translational regulatory elements in the CFTR 5' UTR using DART, discovering stimulatory and repressive features with potential therapeutic applications.

bioRxiv · Oct 19, 2026 · PreprintMolecular Biology

Cellular translational enhancer elements that recruit eukaryotic initiation factor 3

Jiří Koubek, Jaswinder Kaur, Shivani Bhandarkar, Cole J.T. Lewis, Rachel O. Niederer, Andrei Stanciu, Colin Echeverría Aitken, Wendy V. Gilbert

The paper identifies a specific 5'-UTR motif, AMAYAA, that eIF3 binds to, enhancing translation under stress conditions.

RNA · Dec 3, 2024Peer-reviewedSystems Biology

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation

Rachel O. Niederer, María F. Rojas-Durán, Boris Zinshteyn, Wendy V. Gilbert

The paper introduces DART, a method to analyze ribosome targeting, revealing thousand-fold differences in 5' UTR-specific translation activity and identifying regulatory elements.

Cell Systems · Jan 17, 2022Peer-reviewedMolecular Biology

Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro

Yu Sun, Laura Abriola, Rachel O. Niederer, Savannah F. Steinhauser, Mia Madel Alfajaro, Valter Silva Monteiro, Craig B. Wilen, Ya‐Chi Ho, Wendy V. Gilbert, Yulia V. Surovtseva, Brett D. Lindenbach, Junjie U. Guo

This study identifies merafloxacin as a -1 PRF inhibitor that impedes SARS-CoV-2 replication in vitro.

Proceedings of the National Academy of Sciences · Jun 14, 2021Peer-reviewedMolecular Biology