Author

Sofie Van de Velde

Ghent UniversityORCID 0009-0002-3102-418XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:deconvolution· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Katleen De PreteriD· 2 shared Ruben Van PaemeliD· 2 shared Andries De KokeriD· 1 shared Anxhela ZakaiD· 1 shared Björn MenteniD· 1 shared Bram De WildeiD· 1 shared Bram Van GaeveriD· 1 shared Celine EveraertiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Katleen De PreterORCID

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2 papers

Recent·Most cited

A benchmark of DNA methylation deconvolution methods for tumoral fraction estimation using DecoNFlow

Edoardo Giuili, Sofie Van de Velde, Sam Kint, Maisa Renata Ferro dos Santos, Lotte Cornelli, Sofie Roelandt, Kathleen Schoofs, Renske Imschoot, Ruben Van Paemel, Leander Meuris, Celine Everaert, Katleen De Preter

This study benchmarks DNA methylation deconvolution methods for tumoral fraction estimation in cfDNA, finding CelFiE most accurate and introducing DecoNFlow as a comprehensive pipeline.

bioRxiv · Nov 27, 2025 · PreprintBioinformatics

Development of circulating cell-free DNA reduced representation bisulfite sequencing for clinical methylomics diagnostics

Andries De Koker, Lennart Raman, Ruben Van Paemel, Malaïka Van der Linden, Sofie Van de Velde, Paul van der Leest, Bram Van Gaever, Anxhela Zaka, Karim Vermaelen, Ingel Demedts, Veerle Surmont, Ulrike Himpe, Franceska Dedeurwaerdere, Liesbeth Ferdinande, Kathleen Claes, , Nico Callewaert

The paper introduces cf-RRBS, a method for methylation profiling of fragmented plasma DNA, enabling cost-effective and accurate non-invasive lung cancer subtyping.

bioRxiv · Sep 8, 2025 · PreprintGenomics