Development of circulating cell-free DNA reduced representation bisulfite sequencing for clinical methylomics diagnostics
Andries De Koker, Lennart Raman, Ruben Van Paemel, Malaïka Van der Linden, Sofie Van de Velde, Paul van der Leest, Bram Van Gaever, Anxhela Zaka, Karim Vermaelen, Ingel Demedts, Veerle Surmont, Ulrike Himpe, Franceska Dedeurwaerdere, Liesbeth Ferdinande, Kathleen Claes, , Nico Callewaert
The paper introduces cf-RRBS, a method for methylation profiling of fragmented plasma DNA, enabling cost-effective and accurate non-invasive lung cancer subtyping.
bioRxiv · Sep 8, 2025 · PreprintGenomics