Inhibition of formate production blocks CD8+ T-cell responses and delays disease onset in a mouse model of type 1 diabetes
Erika Gabriela Ramirez-Hernandez, Micah Bell, Byung Soo Kong, Samuel Block, Matthew G. Vander Heiden, Nora Kory
This study shows that inhibiting formate production in CD8+ T cells delays type 1 diabetes onset in mice by reducing their activation and effector function.
bioRxiv · Jul 4, 2025 · PreprintImmunology