Nick Lang

This study shows lamin B1 affects nuclear shape and integrity via chromatin stiffness, not lamin stiffness, using mechanical measurements and simulations.

The paper examines chromatin states and transcription dynamics in nuclear blebs, finding variable chromatin states but consistent enrichment of transcription initiation over elongation.

This study shows that nuclear and actin mechanics change from G1 to G2, leading to decreased nuclear stiffness and increased vulnerability to rupture.

The paper measures lamin B and DNA damage in blebbed nuclei to determine the effect of nuclear rupture, finding lamin B loss is rupture-dependent while DNA damage is independent.