Kelsey Prince

The paper shows that transcriptional activity drives chromatin motion, which causes nuclear blebbing, independent of nuclear mechanics or actin antagonism.

The paper examines chromatin states and transcription dynamics in nuclear blebs, finding variable chromatin states but consistent enrichment of transcription initiation over elongation.

The paper measures lamin B and DNA damage in blebbed nuclei to determine the effect of nuclear rupture, finding lamin B loss is rupture-dependent while DNA damage is independent.

This study shows DNA damage reduces heterochromatin via ATM, leading to nuclear softening, blebbing, and rupture in MEF cells.

The paper compares lamin B and DNA levels in nuclear blebs across cell types and perturbations, finding DNA concentration is more consistently reduced than lamin B levels.