ImmunologybioRxivPreprint
Adoptive cell therapy using T cell receptors equipped with ICOS yields durable anti-tumor response
Alexandre PL Marraffa, Cor Berrevoets, Margherita Mosiello…·Reno Debets
This paper designs TCRs with ICOS to improve T cell therapy, showing durable anti-tumor effects and resistance to exhaustion in mice and humans.