Author

Daphne Roelofs

Netherlands Maritime TechnologyORCID 0009-0006-4735-7076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Dora HammerliD· 2 shared Kim KroeseiD· 2 shared Mandy van BrakeliD· 2 shared Rachel J.M. AbbottiD· 2 shared Rebecca WijersiD· 2 shared Reno DebetsiD· 2 shared Alexandre PL MarraffaiD· 1 shared André KunertiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Dora HammerlORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 14, 2025

Adoptive cell therapy using T cell receptors equipped with ICOS yields durable anti-tumor response

Alexandre PL Marraffa, Cor Berrevoets, Margherita Mosiello…·Reno Debets

This paper designs TCRs with ICOS to improve T cell therapy, showing durable anti-tumor effects and resistance to exhaustion in mice and humans.

DOI 10.1101/2025.10.14.682056

𝕏 PostBluesky

ImmunologyCancer DiscoveryPeer-reviewedAug 21, 2024

TCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer in near-clinical models

Dian Kortleve, Dora Hammerl, Mandy van Brakel…·Reno Debets

This study identifies ROPN1 as a target for TCR-engineered T-cells effective against TNBC in preclinical models and demonstrates their safety and efficacy.

16 citations

humanproteomics

𝕏 PostBluesky