Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP-43 low complexity domain
Thomas B. Walker, Joshua W. Trowbridge, Shannon McMahon, Nicholas R. Marzano, Lauren J. Rice, Justin J. Yerbury, Heath W. Ecroyd, Luke McAlary
This paper shows that HspB1 and HspB5 differentially regulate TDP-43LCD condensation and aggregation, with HspB1 increasing dynamic exchange and HspB5 delaying pathological transition.
Protein Science · Mar 19, 2026Peer-reviewedBiochemistry