Author

Christopher Hughes

University of Southern CaliforniaORCID 0009-0002-6919-3384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Anakha AjayaniD· 1 shared Anoop RawatiD· 1 shared Hui XuiD· 1 shared Jeannie CheniD· 1 shared Jose Mario IsasiD· 1 shared Joshua LugoiD· 1 shared Kaori NoridomiiD· 1 shared Natalie S. CheniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Anakha AjayanORCID

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1 paper

Recent·Most cited

Protofibril Binding Peptides Recognize and Inhibit Huntingtin Amyloid Formation in vitro and in vivo

Kaori Noridomi, Jose Mario Isas, Anakha Ajayan, Tristan C. McPhail, Hui Xu, Anoop Rawat, Christopher Hughes, Natalie S. Chen, Joshua Lugo, Terry T. Takahashi, Jeannie Chen, Ralf Langen, Richard W. Roberts

This paper identifies peptides that bind and inhibit huntingtin protofibril formation in vitro and in vivo, offering potential diagnostic and therapeutic applications for Huntington's disease.

bioRxiv · Oct 21, 2025 · PreprintBiochemistry