Author

Ralf Langen

University of Southern CaliforniaORCID 0000-0003-2816-6531Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

Anoop RawatiD· 3 shared Ali KhoshnaniD· 2 shared Jose Mario IsasiD· 2 shared Anakha AjayaniD· 1 shared Anjalika ChongthamiD· 1 shared Baiyi QuaniD· 1 shared Christopher HughesiD· 1 shared Hui XuiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Anoop RawatORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 2, 2026

ENAH Binding to the Huntingtin Proline-Rich Domain Modulates HTT1a Assembly

Jobin Varkey, Anoop Rawat, Priyatama Pandey…·Ali Khoshnan

This study identifies ENAH as an interactor of the HTT1a PRD and shows that EVH1 domain binding modulates HTT1a aggregation and fibril remodeling.

DOI 10.64898/2026.07.29.741051

humanproteomics

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BiochemistrybioRxivPreprintOct 21, 2025

Protofibril Binding Peptides Recognize and Inhibit Huntingtin Amyloid Formation in vitro and in vivo

Kaori Noridomi, Jose Mario Isas, Anakha Ajayan…·Richard W. Roberts

This paper identifies peptides that bind and inhibit huntingtin protofibril formation in vitro and in vivo, offering potential diagnostic and therapeutic applications for Huntington's disease.

DOI 10.1101/2025.10.21.680574

mouseprotein structure

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NeuroscienceNeurobiology of DiseasePeer-reviewedSep 24, 2021

Sonicated fibrils of huntingtin exon-1 preferentially seed neurons and produce toxic assemblies

Anjalika Chongtham, Jose Mario Isas, NITIN KUMAR PANDEY…·Ali Khoshnan

This study shows sonicated HTTex1 fibrils selectively seed neurons, leading to toxic assemblies and neuronal damage.

10 citations

humanprotein structure

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