Author

Jose Mario Isas

University of Southern CaliforniaORCID 0009-0007-8784-0684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anoop RawatiD· 2 shared Ralf LangeniD· 2 shared Ali KhoshnaniD· 1 shared Anakha AjayaniD· 1 shared Anjalika ChongthamiD· 1 shared Christopher HughesiD· 1 shared Hui XuiD· 1 shared Jeannie CheniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Anoop RawatORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 21, 2025

Protofibril Binding Peptides Recognize and Inhibit Huntingtin Amyloid Formation in vitro and in vivo

Kaori Noridomi, Jose Mario Isas, Anakha Ajayan…·Richard W. Roberts

This paper identifies peptides that bind and inhibit huntingtin protofibril formation in vitro and in vivo, offering potential diagnostic and therapeutic applications for Huntington's disease.

DOI 10.1101/2025.10.21.680574

mouseprotein structure

𝕏 PostBluesky

NeuroscienceNeurobiology of DiseasePeer-reviewedSep 24, 2021

Sonicated fibrils of huntingtin exon-1 preferentially seed neurons and produce toxic assemblies

Anjalika Chongtham, Jose Mario Isas, NITIN KUMAR PANDEY…·Ali Khoshnan

This study shows sonicated HTTex1 fibrils selectively seed neurons, leading to toxic assemblies and neuronal damage.

10 citations

humanprotein structure

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