Jeannie Chen

This paper identifies peptides that bind and inhibit huntingtin protofibril formation in vitro and in vivo, offering potential diagnostic and therapeutic applications for Huntington's disease.

This study shows that gene therapy for retinitis pigmentosa is most effective when administered before 50% rod loss, as later treatment fails to restore normal retinal function.

This study shows that cone-mediated signaling remains robust in retinal ganglion cells despite rod photoreceptor degeneration, suggesting gene therapies may still effectively preserve vision.

This study shows that activating rod input in a retinal degeneration model restores synaptic structure, circuitry, and visual signaling in adult mice.