Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defects
Haiyang Luo, Honglin Zheng, Yongting Lu, Chenyang Liu, Kang Zhang, Suying Duan, Hang Zhang, Yaochong Zhang, Y. Song, Tuo Wang, Han Liu, Na Zhang, Zongping Xia, Yuming Xu
This study shows ANXA11 forms prion-like amyloid fibrils through phase separation, which propagate between cells, induce TDP-43 pathology, and disrupt nucleocytoplasmic transport, linking ANXA11 dysfunction to ALS/FTD.
bioRxiv · Mar 26, 2026 · PreprintNeuroscience