Mohammed Al‐Seragi

This study uses a CRISPR screen to identify genes regulating CD44-HA binding in breast cancer, revealing RAB4A as a novel regulator of invasion and potential therapeutic target.

This study uses CRISPR activation screens to identify genetic pathways regulating Siglec-binding glycans in cancer, revealing novel targets for immunotherapy.

This study identifies YibN as a functional interactor of YidC, showing it enhances membrane protein insertion and lipid production in bacteria.

This paper introduces MM-TPP, a method to map membrane protein-ligand interactions using Peptidisc and thermal proteome profiling, showing it detects specific ligand effects on ABC transporters and GPCRs better than detergent-based TPP.

This paper uses structural analysis to show that the β37(C3)Trp->Arg mutation in Hemoglobin Rothschild reduces O2 affinity through both stabilized T-state and dimerized R-state mechanisms.