Ashim Bhattacharya

This paper uses MM-TPP to show that cholesteryl hemisuccinate broadly stabilizes membrane proteins across different systems and membrane mimetics.

This paper introduces Peptergents, a detergent-free method for native membrane proteomics that preserves protein structure and function, enabling better analysis of membrane proteins and their interactions.

This paper introduces a detergent-free method using amphipathic peptides to extract and purify membrane proteins, enabling improved structural and mass spectrometry analysis.

This paper uses membrane-mimetic proteomics to show that AD-related membrane proteome changes are enriched in APP mice, and M1 receptor activation selectively affects disease-altered membrane networks.

This study compares seven membrane proteomic workflows, finding that solid-phase methods capture more total proteins while membrane mimetics enrich membrane proteins, with Peptidisc excelling in detecting dysregulated membrane proteins in diseased liver.

This paper introduces MM-TPP, a method to map membrane protein-ligand interactions using Peptidisc and thermal proteome profiling, showing it detects specific ligand effects on ABC transporters and GPCRs better than detergent-based TPP.