Rupinder Singh Jandu

This study compares seven membrane proteomic workflows, finding that solid-phase methods capture more total proteins while membrane mimetics enrich membrane proteins, with Peptidisc excelling in detecting dysregulated membrane proteins in diseased liver.

This paper introduces MM-TPP, a method to map membrane protein-ligand interactions using Peptidisc and thermal proteome profiling, showing it detects specific ligand effects on ABC transporters and GPCRs better than detergent-based TPP.