Cell BiologybioRxivPreprint
The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity
Stephanie Fernandes, Jiyoung Pan, Diana S. Terziyska…·Constantinos Demetriades
This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.
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