Author

George Mosialos

Aristotle University of ThessalonikiORCID 0000-0002-5342-4873Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aurelio A. TelemaniD· 1 shared Christos GonidasiD· 1 shared Constantinos DemetriadesiD· 1 shared David Vı́lcheziD· 1 shared Diana S. Terziyska· 1 shared István Balázs NémethiD· 1 shared Jiyoung PaniD· 1 shared Julian NücheliD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Aurelio A. TelemanORCID

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1 paper

Recent·Most cited

The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity

Stephanie Fernandes, Jiyoung Pan, Diana S. Terziyska, Seda Koyuncu, Xiaolei Ding, István Balázs Németh, Sabine Wilhelm, Julian Nüchel, Suzan Al-Gburi, Christos Gonidas, Manolis Pasparakis, George Mosialos, Márta Széll, Aurelio A. Teleman, Sabine Anne Eming, , Constantinos Demetriades

This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.

bioRxiv · Sep 1, 2025 · PreprintCell Biology