Jiyoung Pan

The paper identifies ATM-dependent RHEB phosphorylation as a mechanism linking DNA damage to lysosomal mTORC1 signaling, which regulates TFEB and lysosome biogenesis during genotoxic stress.

This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.