Author

Jiuhong Nan

Second Affiliated Hospital of Zhejiang UniversityORCID 0000-0002-4355-7015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:Ribo-seq· 1 Approach:transformer / foundation model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Xushen XiongiD· 2 shared Baizhou LiiD· 1 shared Bo-Xin Zhang· 1 shared Carles A. BoixiD· 1 shared Chengyu LiiD· 1 shared Dan WuiD· 1 shared Dong FangiD· 1 shared Huan-Feng Ye· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Xushen XiongORCID

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2 papers

Recent·Most cited

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

Wei Liu, Song-Ang Wu, Bo-Xin Zhang, Shaoyu Guo, Lang Li, Wenjing Sun, Xushen Xiong, Jiuhong Nan, Jianfeng Wu, Linghui Zeng, Pilong Li, Zhiyu Cai, Huan-Feng Ye, Shuo Zhang, Sheng Nie, , Wei Mo

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

bioRxiv · Feb 17, 2026 · PreprintNeuroscience

Deep learning modeling of ribosome profiling reveals regulatory underpinnings of translatome and interprets disease variants

Jialin He, Lei Xiong, Shaohui Shi, Chengyu Li, Kexuan Chen, Qianchen Fang, Jiuhong Nan, Ke Ding, Jingyun Li, Yuanhui Mao, Carles A. Boix, Xinyang Hu, M Kellis, Xushen Xiong

The paper introduces Translatomer, a transformer model that predicts cell-type-specific translation from mRNA and sequence data, identifies disease variants affecting translation, and reveals non-eQTL regulatory mechanisms.

bioRxiv · Feb 26, 2024 · PreprintGenomics