Chenbo Zeng

This study shows that the LRRK2-R1441G mutation causes age-related mitochondrial dysfunction and oxidative stress in dopamine neurons, suggesting calcium channels and uncoupling proteins as therapeutic targets.

This study shows that quinpirole improves microglial dysfunction in LRRK2-R1441G transgenic mice by reversing motility and responsiveness issues.

This study identifies the Sigma-2 receptor/TMEM97, PGRMC1, and LDLR complex as a pathway for Aβ42 uptake in neurons, both with and without apoE, suggesting it as a potential therapeutic target for Alzheimer's disease.