Cancer BiologyCancer Gene TherapyPeer-reviewed
Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerability
Rohit Sivaprasad, Kristijonas Žemaitis, David Linfeldt…·Agatheeswaran Subramaniam
This study models KBTBD4 mutations in hematopoietic stem cells, identifies HDAC inhibitors as therapeutic agents, and reveals their mechanism of action.
DOI 10.1038/s41417-026-01068-x