Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerability
Rohit Sivaprasad, Kristijonas Žemaitis, David Linfeldt, Sudip Ghosh, Anne de Snaijer, Mattias Magnusson, Fredrik Ek, Jenny Hansson, Agatheeswaran Subramaniam
This study models KBTBD4 mutations in hematopoietic stem cells, identifies HDAC inhibitors as therapeutic agents, and reveals their mechanism of action.
Cancer Gene Therapy · Aug 10, 2026Peer-reviewedCancer Biology