Fredrik Ek

Bioresorbable, Injectable In Situ-Formed Electroactive mRNA-Delivering Device for Precision Gene Therapy after Myocardial Infarction

This paper develops an injectable, bioresorbable device for localized mRNA delivery to the heart after myocardial infarction, showing improved cardiac function and reduced remodeling in mice.

Injectable Nanoparticles Assemble In Situ into Modular, Functionally Segmented Brain Electrodes

The paper develops injectable nanoparticles that form soft, functionally segmented brain electrodes capable of neuronal stimulation and gene transfer in chicken embryos.

Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerability

This study models KBTBD4 mutations in hematopoietic stem cells, identifies HDAC inhibitors as therapeutic agents, and reveals their mechanism of action.

Lithography-free Water Stable Conductive Polymer Nanowires

This paper presents a lithography-free method to create water-stable conductive polymer nanowires for interfacing with biological cells.

FRET-based screening in HEK293T identifies p38 MAPK and PKC inhibition as therapeutic targets for α-synuclein aggregation