Xingyan Ye

This study identifies a specialized proteasome structure in mature mammalian sperm using cryo-EM, revealing that PAC1/2 repurposes from a chaperone to a stable regulator, defining a hyperactive 20S variant.

This study investigates how LCA-linked mutations in TRiC/CCT subunit CCT2 disrupt its allosteric network and functional cycle, leading to structural and functional defects associated with Leber Congenital Amaurosis.

This study reveals the mechanism by which the 26S proteasome recognizes and degrades ODC without ubiquitin, through cryo-EM structures showing dynamic interactions and translocation processes.