Qiaoyu Zhao

This study elucidates the TRiC-assisted folding of class I HDACs, revealing distinct co-chaperone and cofactor networks for HDAC1 and HDAC3, while HDAC8 folds independently.

This study reveals how TRiC folds the large ciliary protein IFT172 using a non-canonical open-state mechanism involving Z-shaped bending and fold-and-eject dynamics.

This study investigates how LCA-linked mutations in TRiC/CCT subunit CCT2 disrupt its allosteric network and functional cycle, leading to structural and functional defects associated with Leber Congenital Amaurosis.

The paper develops an immobilized antibody-based affinity grid strategy to improve cryo-EM sample preparation by enabling on-grid purification of target proteins and overcoming orientation issues.

This study uses cryo-EM to reveal conformational dynamics of SARS-CoV-2 spike trimer in complex with ACE2, showing how ACE2 binding triggers structural changes and enhanced infectivity.