Author
Chinese Academy of Sciences
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Zuyang Li, Qiaoyu Zhao, Wanying Jiang, Qianqian Song, Xuehai Zhou, Xiangyi Shi, Qing Zhang, yanxing wang, Yinghong Lin, Yue Yin, Pan Chen, Yao Cong
This study elucidates the TRiC-assisted folding of class I HDACs, revealing distinct co-chaperone and cofactor networks for HDAC1 and HDAC3, while HDAC8 folds independently.
Science Advances · Jul 15, 2026Peer-reviewedMolecular Biology
Xuehai Zhou, Linlin Shen, Xuyang Yuan, Chen Chen, Tingfeng Wang, Zuyang Li, Jiahao Peng, Xianze Lang, Xingyan Ye, Tian Chen, Kaijian Chen, Chen Su, Zhong Huang, Yao Cong
This study identifies a specialized proteasome structure in mature mammalian sperm using cryo-EM, revealing that PAC1/2 repurposes from a chaperone to a stable regulator, defining a hyperactive 20S variant.
bioRxiv · Jun 2, 2026 · PreprintCell Biology
Qiaoyu Zhao, Jiayi Li, Yujie Tong, Yurui Li, Wenyu Han, Zuyang Li, yanxing wang, Yue Yin, Jun Fang, Wanying Jiang, Qianqian Song, Shengyou Huang, Yidong Shen, Yao Cong
This study reveals how TRiC folds the large ciliary protein IFT172 using a non-canonical open-state mechanism involving Z-shaped bending and fold-and-eject dynamics.
bioRxiv · Mar 31, 2026 · PreprintBiochemistry
Qiaoyu Zhao, Caixuan Liu, Qing Zhang, Zuyang Li, Yanxing Wang, Xuehai Zhou, Xingyan Ye, Shanshan Wang, Yanke Wang, Wanying Jiang, Qianqian Song, Yao Cong
This study investigates how LCA-linked mutations in TRiC/CCT subunit CCT2 disrupt its allosteric network and functional cycle, leading to structural and functional defects associated with Leber Congenital Amaurosis.
bioRxiv · Jan 23, 2026 · PreprintBiochemistry