Lorenzo Edwin Ferri

This study shows that neutrophil extracellular traps (NETs) in lymph nodes create an immunosuppressive environment that promotes metastasis by altering Treg and CD8 T cell function and organization.

This study links circulating myeloid dysfunction, measured by cNLR, to tumour spatial organization in GEA through multiscale analyses of immune function, single-cell transcriptomics, and spatial myeloid organization.

The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.

The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.

The paper establishes a large-scale biobank of GEA patient-derived organoids that accurately model tumor features and drug responses, enabling personalized treatment strategies.

This study identifies immune cell changes and gene expression patterns in Barrett's esophagus progression to cancer using spatial and multi-omic analyses.

The paper introduces a probabilistic model to estimate and correct sample index hopping in single-cell RNA-seq data, reducing phantom molecules by up to 85%.