Thomas J.R. Frith

The paper shows that a truncated ASH2L isoform, generated via a lineage-specific retrotransposon, primes developmental gene promoters during pluripotency and is required for later developmental transitions.

The paper uses genomic barcoding and single-cell RNA sequencing to reveal hierarchical lineage architecture in human and avian spinal cord development, showing conserved lineage restriction and developmental routes.

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

This study shows Notch signalling promotes mesodermal fate and HOX gene activation in human NMPs while inhibiting neural fate through a feedback loop with FGF.

This study identifies TBXT's role in early posterior regionalisation of human neural crest cells through chromatin remodelling and WNT signalling.

This study shows retinoic acid accelerates the generation of enteric neural progenitors from human pluripotent stem cells, which can form enteric neurons and colonize the ENS in mice.

This study identifies that human axial progenitors generate trunk neural crest cells and defines their molecular signatures.