Author

Megan Lynn Proffer

Indiana University IndianapolisORCID 0009-0002-9247-2787Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Abigail TwoyiD· 1 shared Anup R. SharmaiD· 1 shared CATE SPEAKEiD· 1 shared Emily Soohoo· 1 shared Everett H. MeyeriD· 1 shared Farooq SyediD· 1 shared Jason M. SpaethiD· 1 shared Jon D. PiganelliiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Abigail TwoyORCID

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1 paper

Recent·Most cited

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses.

Saptarshi Roy, Megan Lynn Proffer, Farooq Syed, Megan E. Smithmyer, Anup R. Sharma, Abigail Twoy, Emily Soohoo, Jyoti Rana, Jason M. Spaeth, Everett H. Meyer, Kent P. Jensen, CATE SPEAKE, William Hagopian, Jon D. Piganelli

This study identifies soluble LAG-3 (sLAG-3) as an early biomarker of T cell activation in type 1 diabetes, detectable before islet autoantibody development and associated with beta-cell stress and high-risk HLA genotypes.

bioRxiv · Apr 2, 2026 · PreprintImmunology