Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
Marián Hruška-Plocháň, Katharina M. Betz, Silvia Ronchi, Vera I. Wiersma, Zuzanna Maniecka, Eva‐Maria Hock, Florent Laferrière, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Martina Panatta, Alexander van der Bourg, Dáša Bohačiaková, Karl Frontzek, Adriano Aguzzi, , Magdalini Polymenidou
The paper develops a human iPSC-derived neural model to study TDP-43 pathology, identifying NPTX2 misregulation as a key factor in ALS/FTLD neurotoxicity.
bioRxiv · Dec 8, 2021 · PreprintNeuroscience