α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin
Jeanne M. Quinn, Phuong M. Le, Anthea Weng, Annette S. Flozak, Stephen Sai Folmsbee, Erik Arroyo-Colon, Mitsuhiko Ikura, Noboru Ishiyama, Cara J. Gottardi
This study shows that α-catenin phosphorylation, regulated by actomyosin contractility, is essential for epithelial barrier function through its interaction with Afadin.
bioRxiv · Aug 21, 2025 · PreprintCell Biology