Rachael Springman-Rodriguez

CODMA-A3 is a high-throughput assay for screening APOBEC3 variants, detecting substrate competition and activity changes without protein purification.

The paper identifies APOBEC3A and APOBEC3B mutagenic effects in HPV-positive HNSCC by analyzing single-cell data, showing distinct mutational signatures linked to tumor stages and vaccine targets.

The paper deconvolves HIV-1 mutational signatures across anatomical compartments and identifies APOBEC3-associated mutagenesis as a major contributor, showing donor-specific patterns.

This study identifies APOBEC3G splicing defects in nonhuman primates that lead to different viral mutation profiles compared to humans.