Jake D. Lehle

CODMA-A3: A Competitive Oligo-based DNA Modification Assay Applied to APOBEC Enzymes

CODMA-A3 is a high-throughput assay for screening APOBEC3 variants, detecting substrate competition and activity changes without protein purification.

Deciphering the Network Architecture of APOBEC3-Driven Mutagenesis in HPV-Positive Head and Neck Cancers

The paper identifies APOBEC3A and APOBEC3B mutagenic effects in HPV-positive HNSCC by analyzing single-cell data, showing distinct mutational signatures linked to tumor stages and vaccine targets.

Deconvolution of HIV-1 Mutational Signatures Reveals Dominant and Donor-Specific APOBEC3-Associated Mutagenesis Across Anatomical Compartments

The paper deconvolves HIV-1 mutational signatures across anatomical compartments and identifies APOBEC3-associated mutagenesis as a major contributor, showing donor-specific patterns.

APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to Humans

This study identifies APOBEC3G splicing defects in nonhuman primates that lead to different viral mutation profiles compared to humans.

Endocrine disruptor-induced epimutagenesis in vitro: Insight into molecular mechanisms

This study investigates how endocrine disruptors like BPS induce epimutations in different cell types and how these changes persist through cell differentiation and generations.